New method 上海高端工作室微信 helps the immune system to find and destroy cancer cells
According to the paper on the 26th, the discipline of the National Academy of Sciences, the UK Southampton University and the research staff of the Italian National Genetics Institute have identified a potential treatment, which can improve the human immune system to find and destroy the body. The ability of cancer cells: By limiting a group of cells that regulate the immune system, other immune cells are released to attack tumors of cancer patients. "Immunohotherapy has recently become a new therapy for multiple cancers.
"Leading this study of the Southampton University Cell Signal Professor Nurun Diwa explained that" however, cancer cells can produce a micro-ring that prevents the immune system work in the tumor, thus limiting the general 上海水磨干磨桑拿会所 use of immunotherapy and success. "The immune system should detect and remove cancer cells, which are completed by cells called effect T cells (TEFF), and the effect of detecting and removing cancer cells depends to a certain degree depending on the modified T cells (Treg )Cell.
Treg is physically interacting with TEFF cells, and the molecules thereof will reduce the ability of TEFF cells. Treg cells play an important role in the human body. If they do not, the immune system will be out of control, attacking the normal cells of the human body. The molecules released by cancer cells will further reduce the activity and function of TEFF cells by attracting and accumulating TREG cells. The researchers said that there is indeed a mechanism for suppressing Treg cells.
However, these mechanisms generally lead to inhibition of TEFF cells due to Treg cells and TEFF cells. For cancer patients, we need more "free" to TEFF cells to complete their work. Researchers have found that inhibiting a group of enzymes called PIP4K in cells can inhibit Treg cells without affecting TEFF cells.
They separated Treg cells from a health donor and using genetic techniques to inhibit PIP4K production.
They found that the lack of PIP4K in Treg cells will prevent their growth and reactions to immune signals, thereby blocking it inhibiting the activity and function of TEFF cells.
At the same time, there is no activity to limit the PIP4K in TEFF cells. Dr. Alexandro Polley said that PIP4K is similar in two types of T cells, but its effect on Treg cells seems to be more important than TEFF cells.
The use of a drug similar to a PIP4K inhibitor is 上海sh419 treated, and the function of the immune system can be more functional and better destroying cancer cells.
General Edge Circle This T is non-He T. Although it is called T cells, the ability of Treg and TEFF interacts, the ability of the latter will decrease, that is, the ability to detect and remove cancer cells will decrease.
If you can suppress TREG cells, you can combat TEFF cells more freedom.
But the problem is that these two are very similar, inhibiting this T, will also hurt the T.
It is better to find PIP4K enzyme in researchers, which seem more important to Treg cells, and it is not necessary to TEFF.
This paragraph is a winding, in short, we conclude that this method can be the help of immunotherapy.
(Internship reporter Zhang Jiaxin).